Technology

Precision Deimmunization with Our ADAx Platform

The ADAx platform is an innovative technology that incorporates proprietary CD22 ligands (CD22L) on biologics to target and suppress therapeutic-specific B cells, while preserving the full functionality of the biologic.

Our Novel Approach

Tuned Affinity & Specificity

We’ve optimized natural CD22 ligands with enhanced binding affinity and specificity, enabling precise and targeted immune modulation.

Enhanced Pharmacological Activity

Our CD22L-conjugated biologics are designed to maintain full pharmacologic function while enhancing the therapeutic profile.

Safety & Durability

Our deimmunized biologics are designed to minimize immune responses and reduce adverse events while ensuring long-term therapeutic efficacy.

Our Mechanism - ADAx Pathway

Key features of our ADAx platform

  • Selectively suppresses B cell receptor (BCR) activation specific to the therapeutic while preserving normal immune responses
  • Cross-species reactivity of CD22 ligand enables preclinical evaluation of ADA suppression in vivo
  • Demonstrated compatibility with various protein formats including antibodies, bispecifics, multi-domain proteins, and enzymes.
  • Unlike other ADA mitigation techniques, ADAx avoids broad immune suppression, does not rely on epitope masking, and does not alter the tissue distribution of the drug.
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